RAF Typhoon jets have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syria operated by the IS group, as stated by the British defence ministry.
The location, identified by surveillance, was believed to be containing munitions and bombs, the release indicated, and was positioned in mountainous terrain just north of the ancient city of Palmyra in central Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to target a several approach shafts down to the site... preliminary assessments indicate the target was engaged successfully," the MoD said.
There was no sign of any civilian impact in the attack late on Saturday and all the aircraft returned safely, the defence officials confirmed.
The British jets were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - established militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates our UK leadership, and determination to operate in unison with allied nations, to eliminate any re-emergence of Daesh and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary stated.
British military aircraft have conducted surveillance missions over Syria to "deter any attempted comeback" of the group following its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank all the members of our armed forces involved in this mission for their professionalism and their courage," the Defence Secretary commented. "Including them were a great many British personnel on duty over the holidays. This action, to eliminate militants who threaten our way of life, demonstrates how UK forces are prepared to act, continuously, ensuring Britain's security within its borders and powerful internationally."
Last December, the American forces conducted what it termed a "massive strike" on Islamic State objectives in Syria, subsequent to an ambush claimed the lives of two American soldiers and a civilian linguist in the Palmyra area.
The UN says Daesh still boasts an estimated 5,000 to 7,000 combatants in Iraq and Syria.